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STRUCTURE AND FUNCTION OF CORTICAL CIRCUITS

WHAT  
WE DO

We study the anatomical organization and function of neural circuits in the visual cortex to understand how these circuits compute the cortical computations that generate perception. We use a multidisciplinary approach encompassing neuroanatomical methods, array electrophysiology, brain imaging, optogenetics and computational modeling to understand how specific circuit wiring leads to cortical neuron responses.

NSF BRAIN GRANT

Alessandra Angelucci (Ophthalmology) and Valerio Pascucci (SCI) receive NSF BRAIN grant to develop a computational infrastructure...

NIH BRAIN GRANT

Alessandra Angelucci (Ophthalmology), Steve Blair and Loren Reith (ECE), receive NIH BRAIN GRANT to develop an hybrid array for large...

NEWS

University of Utah President Ruth Watkins has appointed two John A. Moran Eye Center researchers to endowed professorships. Alessandra Angelucci, MD, PhD, now holds....

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The animal brain is so complex, it would take a supercomputer and vast amounts of data to create a detailed 3-D model of the billions of neurons that power it....

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Interactive software tool lets brain researchers explore large-scale, high-res imaging to better understand connections in the brain......

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Lack of knowledge of the complex organization of visual cortex and inability to reproduce patterns of signaling required by cortex have prevented such "synthetic vision"...

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RECENT PUBLICATIONS

2017

Angelucci A., Bijanzadeh M., Nurminen L., Federer, F., Merlin S. and Bressloff P.C. (2017) Circuits and mechanisms for surround modulation in visual cortex. Ann. Rev. Neurosci. 40: 425-451

2017

Nurminen, L., Merlin S., Bijanzadeh M., Federer F. and Angelucci A. (2017) Top-down feedback controls spatial summation and response gain in primate visual cortex. BioRxiv, doi:https://doi.org/10.1101/094680. Currently undergoing revision in Nature Communications

2017

Petruzza S., Venkat A., Gyulassy A., Scorzelli G., Federer F., Angelucci A., Pascucci V. and Bremer P.-T. (2017). ISAVS: Interactive scalable analysis and visualization system. SIGGRAPH ASIA 2017 Symposium on Visualization. ACM.

MAIN RESEARCH
INTERESTS

 

√ Feedforward connections between visual cortical areas
  and feedforward processing;
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√ Feedback connections between visual cortical areas and
  feedback processing;
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√ Connectomics, and development of computational
  approaches for large scale connectomics;
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√ Contextual effects in visual cortex;
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√ Development of tools for large scale simultaneous
  optogenetics and recordings;
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√ Restoring Vision: visual cortical prosthesis

OUR RESEARCH IS SUPPORTED BY :

  • The National Science Foundation: IOS and EAGER BRAIN Initiative grants
  • The National Eye Institute: 2 R01 grants
  • The National Institute for Neurological Disorders and Stroke: U01 BRAIN Initiative grant
  • The University of Utah Neuroscience Initiative: Seed grant
  • University of Utah Moran Eye Institute and Dept. of Neurosurgery: Seed grant